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| Allain, Thibault; Chaouch, Soraya; Thomas, Myriam; Travers, Marie-agnes; Valle, Isabelle; Langella, Philippe; Grellier, Philippe; Polack, Bruno; Florent, Isabelle; Bermudez-humaran, Luis G.. |
| Giardia duodenalis is a protozoan parasite responsible for giardiasis, a disease characterized by intestinal malabsorption, diarrhea and abdominal pain in a large number of mammal species. Giardiasis is one of the most common intestinal parasitic diseases in the world and thus a high veterinary, and public health concern. It is wellestablished that some probiotic bacteria may confer protection against this parasite in vitro and in vivo and we recently documented the implication of bile-salt hydrolase (BSH)-like activities from strain La1 of Lactobacillus johnsonii as mediators of these effects in vitro. We showed that these activities were able to generate deconjugated bile salts that were toxic to the parasite. In the present study, a wide collection of... |
| Tipo: Text |
Palavras-chave: Giardia duodenalis; Lactobacilli; Lactobacillus johnsonii; Lactobacillus gasseri; Probiotics; Bile salt hydrolases. |
| Ano: 2018 |
URL: https://archimer.ifremer.fr/doc/00424/53569/54417.pdf |
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| Travers, Marie-agnes; Sow, Cisse; Zirah, Severine; Deregnaucourt, Christiane; Chaouch, Soraya; Queiroz, Rayner M. L.; Charneau, Sebastien; Allain, Thibault; Florent, Isabelle; Grellier, Philippe. |
| Giardiasis, currently considered a neglected disease, is caused by the intestinal protozoan parasite Giardia duodenalis and is widely spread in human as well as domestic and wild animals. The lack of appropriate medications and the spread of resistant parasite strains urgently call for the development of novel therapeutic strategies. Host microbiota or certain probiotic strains have the capacity to provide some protection against giardiasis. By combining biological and biochemical approaches, we have been able to decipher a molecular mechanism used by the probiotic strain Lactobacillus johnsonii La1 to prevent Giardia growth in vitro. We provide evidence that the supernatant of this strain contains active principle(s) not directly toxic to Giardia but able... |
| Tipo: Text |
Palavras-chave: Giardiasis; Lactobacilli; Probiotics; Microbiota; Bile salts; Anti-giardial activity; Choloylglycine bile acid hydrolase. |
| Ano: 2016 |
URL: http://archimer.ifremer.fr/doc/00351/46211/45906.pdf |
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